Spravato
(esketamine)Spravato (esketamine), a ketamine derivative nasal spray that rapidly relieves symptoms of depression
Rapid results, highly effective
FDA-approved
Covered by most insurances
Highly Effective.
Life Changing Results.
Lasting Results
Patients sawgreater symptom improvementsfrom depression with 4 weeks of Spravato treatment compared to a placebo
Rapid Relief
A study showed a40% decline in depressionsymptoms on day one compared to a placebo
Covered by Insurance
Spravato is covered bymost insurance plans
Safe & Effective
Spravato isFDA-approved to treat depression, ensuring its quality
and safety
Minimal Side Effects
Some patients reportmild side effectslike dizziness, which typically go away in a few hours
How does Spravato (esketamine) work?
Euphoric and Energizing.
SpravatoworksbytargetingNMDAreceptorsinthebraintoinfluenceglutamatelevels,whichareassociatedwithmoodregulation.Byactivatingthesereceptors,Spravatocanhelpimprovedepressivesymptomsandproviderelief,forpeoplewhohaven’tfoundsuccesswithothertherapies.
Financial support is available
As low as $10/session
Patientscanpayaslittleas$10foreachSpravatoappointmentthroughthecost-savingsprogramslikeSpravatoWithMe&more.TheserebateprogramscandrasticallyreduceyourSpravatotreatmentcosts,dependingonyourout-of-networkbenefitsandcurrentdeductible.
What should I expect from Spravato Treatment?
1
Initial Consultation
A clinician will review your medical history, & assess prior treatments to ensure Spravato is right for you.
2
Insurance or Payment Plan
Spravato is covered by most major insurance plans, particularly when other treatments have not been effective.
3
Spravato Treatment Course
~2x/week, gradually reduced according to your care plan
Rapid relief in 1-2 hours
Spravato is self-administered nasal spray under the supervision of a healthcare professional. You will relax at the clinic for ~2 hours.
4
Continued Support
Many patients report significant improvements in mood and well-being. Your care team will work with you to develop a long-term treatment plan and offer resources for ongoing support.
Find a clinic offering Spravato near me
Find a Spravato provider that meets your insurance & personal preferences in the Big Leap directory
What patients say
about Spravato Therapy
"I was living with moderate to severe depression for all of my adult life. Since completing TMS, my depression is in complete remission and my anxiety is significantly reduced." Full Name
"I was living with moderate to severe depression for all of my adult life. Since completing TMS, my depression is in complete remission and my anxiety is significantly reduced." Full Name
"I was living with moderate to severe depression for all of my adult life. Since completing TMS, my depression is in complete remission and my anxiety is significantly reduced." Full Name
"I was living with moderate to severe depression for all of my adult life. Since completing TMS, my depression is in complete remission and my anxiety is significantly reduced." Full Name
Spravato (Esketamine) vs. TMS vs. IV/IM Ketamine Infusions
Understanding the Differences
How it works
TMS
(Transcranial Magnetic Stimulation)Magnetic pulses stimulate specific brain areas to relieve symptoms over several weeks
Spravato
(Esketamine)Targets NMDA receptors to regulate mood and relieve symptoms
IV/IM Ketamine
Infusions Also targets NMDA receptors felt within the first hour
Treatment
TMS
(Transcranial Magnetic Stimulation)20-40 minutes, magnetic pulses to the brain, awake during treatment
Spravato
(Esketamine)Self-administered nasal spray, administered under supervision
IV/IM Ketamine
Infusions Injection into the vein (IV) or muscle (IM)
Side Effects
TMS
(Transcranial Magnetic Stimulation)Very mild: scalp discomfort or headache
Spravato
(Esketamine)Mild: dizziness, nausea, dissociation
IV/IM Ketamine
Infusions Mild to moderate: nausea, elevated heart rate, dissociation
Treatment Course
TMS
(Transcranial Magnetic Stimulation)30-36 sessions over several weeks
Spravato
(Esketamine)2x/week, tapered over time
IV/IM Ketamine
Infusions Often starts with multiple infusions per week, tapering as symptoms improve
Insurance Coverage
TMS
(Transcranial Magnetic Stimulation)Covered by most plans
Spravato
(Esketamine)Covered by most plans
IV/IM Ketamine
Infusions Generally not covered by insurance, with a full course of treatment costing $3,000–$10,000
Recent clinical research on Spravato
2024
J&J seeks U.S. FDA approval of SPRAVATO® (esketamine) as the first and only monotherapy for adults with treatment-resistant depression•JNJ
2024
When used with an OAD, ESK demonstrates itself as a beneficial supplement in the treatment of TRD & MDD with acute suicidal intent.•Suneeta, et al.
2019
Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant•Bahr et al.
Frequently Asked Questions about Spravato Therapy
What is Spravato (Esketamine) Therapy?
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How is Spravato different from traditional antidepressants?
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Is Spravato covered by insurance?
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What side effects can I expect from Spravato?
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Who is a good candidate for Spravato therapy?
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How long does each Spravato session last?
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How soon will I see results with Spravato?
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How long do the effects of Spravato last?
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What are the downsides of Spravato?
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Who should not use Spravato?
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